The Digest.

Something You Should Know · Podcast summary

The Nocebo Effect: Placebo’s Evil Twin & Weird Facts You Never Knew

Helen Pilcher, a science writer with a PhD in neuroscience, joins Mike Carruthers to discuss the fascinating and unsettling phenomenon of the nocebo effect, the "evil twin" of the placebo effect. Jess Zafarris, an author and language expert, then shares surprising origins of everyday words and fascinating facts about inventions and popular culture.

The Nocebo Effect: Placebo’s Evil Twin & Weird Facts You Never Knew Listen on the show ↗

The digest

Solving Problems and the Nocebo Effect

Mike Carruthers kicks off the episode by offering a simple yet effective strategy for problem-solving and idea generation: taking a walk. Stanford researchers found that creative output increased by an average of 60% when people were walking, even on a treadmill facing a blank wall. This suggests that the benefit isn't just from fresh air or interesting scenery, but from the act of walking itself. This creative boost even lingered after people sat back down. However, this method is particularly good for generating many possible ideas or a fresh approach, not for finding one precise correct answer.

Carruthers then introduces the concept of the nocebo effect, the darker counterpart to the well-known placebo effect. Helen Pilcher, a science writer and former scientist with a PhD in neuroscience, explains how simply being told that something might make you sick can actually increase the chances of you feeling sick. This isn't an imaginary illness; these symptoms can be quite real. Pilcher, author of "This Book May Cause Side Effects: The Curious and Dangerous Power of the Nocebo Effect, Placebo's Evil Twin," delves into how our expectations can sometimes produce very real symptoms.

Keep reading in The Digest

The full 2-minute article, 2 more sections, and every new episode from Something You Should Know and the creators you follow.

  1. Understanding the Nocebo Effect
  2. The Power of Expectation: Real-World Examples
Read the full digest — free

More from Something You Should Know

The Tech of Tomorrow That Never Arrived & The Remarkable History of Teeth - SYSK Choice

Nicole Coby and Bill Schutt explore why some anticipated technologies like flying cars remain elusive and reveal the fascinating evolutionary history and social significance of human teeth.

October 3, 2026

How to Read a Room Like a Pro & The Surprising Truth About Self-Esteem

Pamela Meyer reveals how to master the art of reading social dynamics, while Dr. Marissa Franco uncovers the surprising science behind self-esteem and how to truly build it.

September 28, 2026

Why Pets Behave So Strangely & The Surprising Rhythm of Your Brain - SYSK Choice

Entomologist Eleanor Spicer Rice reveals surprising truths about pet behaviors, while Dr. Mitou Steroni explains how tuning your brain's natural rhythms can boost work performance.

September 26, 2026

How Optimism Works in Tough Times & The Curious Story of Breakfast Cereal

Michelle Geelan explores resilient optimism as a behavior that sustains positivity in tough times, while Marion Nestle reveals the fascinating history and marketing of breakfast cereal.

September 24, 2026

Stop Trying So Hard to Sleep & Why New Things Are So Hard to Resist

Sleep physiologist Stephanie Romaszewski explains why our obsession with optimizing sleep is counterproductive, and author Eric Athas discusses why new things are so hard to resist.

September 21, 2026

How Horses Shaped History & The Surprising Upside of Laziness – SYSK Choice

Historian Timothy Weingard discusses the profound impact of horses on human history, from ancient civilizations to modern society. Author Todd McElroy explores the surprising benefits of strategic laziness for increased productivity and well-being.

September 19, 2026

All Something You Should Know summaries →